Progesterone effects during sequential hormone replacement therapy

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CLINICAL STUDY Progesterone effects during sequential hormone replacement therapy

Objective: The aim was to investigate the effect on mood and the physical symptoms of two dosages of natural progesterone and a placebo in postmenopausal women with and without a history of premenstrual syndrome (PMS). Design: A randomized, placebo-controlled, double-blind, crossover study was performed. Method: Postmenopausal women ðn 1⁄4 36Þ with climacteric symptoms were recruited. They rece...

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The relative effects of progesterone and progestins in hormone replacement therapy.

Hormone replacement therapy (HRT) was initially given to protect women against osteoporosis and alleviate menopausal symptoms, such as hot flashes, depression, sleep disturbances, and vaginal dryness. In view of the understanding of oestrogen deficiency as a major trigger for the acceleration of cardiovascular risk after menopause, HRT may also be proposed as a substantial beneficial cardioprot...

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The effects of progesterone selection on psychological symptoms in hormone replacement therapy.

OBJECTIVES The aim of this study is to evaluate the effects of hormone replacement therapy using dienogest and medroxyprogesterone acetate on psychological symptoms in perimenopausal and postmenopausal women. MATERIAL AND METHODS A total of 73 patients who sought treatment at the menopause units of the authors' gynecology and obstetrics clinics between of November 2003 and October 2004 compla...

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Hormone replacement therapy: prothrombotic vs. protective effects.

Hormone replacement therapy (HRT) is associated with reduced risk of coronary heart disease (CHD) and stroke in observational studies; however the possibility of confounding by other risk factors requires prospective assessment of its risks and benefits in randomised controlled trials. The HERS trial of oral HRT in secondary CHD prevention observed an early increased risk of myocardial infarcti...

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Hormone replacement therapy and effects on mood

Hormone replacement therapy and effects on mood Inger Björn Background: During the past 5 decades, hormone replacement therapy (HRT) has been used, and appreciated for its beneficial effects, by millions of women in their menopause. As treatment for climacteric symptoms, estrogen is outstanding, and effects on hot flushes, vaginal dryness, and insomnia have been widely documented. The increased...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2003

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje.0.1480571